Method Development and Coupled Column Systems
To get more out of an LC-instrument than just the separation power of a single column, we have developed an automatic column coupler that can tune the length and the composition of a serially connected train of columns the efficiency and selectivity needs of the sample.We are currently also developing software that can steer this hardware in an autonomous and intelligent way. As a spin-off of this work we also expect to develop novel strategies to enhance method development.
Cabooter, D., Decrop, W., Eeltink, S., Swart, R., Ursem, M., Lestremau, F., Desmet, G.; Automatic Column Coupling System To Operate Chromatographic Supports Closer To Their Kinetic Performance Limit and To Enhance Method Development; 2010; Analyical Chemistry; 82; 1054-1065
Eva Tyteca, Anuschka Liekens, David Clicq, Ameriga Fanigliulo, Benjamin Debrus , Serge Rudaz, Davy Guillarme, Gert Desmet, Predictive Elution Window Stretching and Shifting as a Generic Search Strategy for Automated Method Development, Anal. Chem., in press
Involved Staff: Gert, Eva, Yoachim, Prof. Deirdre Cabooter (KULeuven, external collaboration)