Dr. Jelle De Vos
Telephone: +32 (0)2 629 1156
Degree obtained: Master of Science in Chemistry
Function: Postdoctoral researcher
I obtained my Master of Science in Chemistry at Ghent University in 2012. For my master thesis, I conducted research at CHIS (Vrije Universiteit Brussel) under the mentorship of Prof. Eeltink, Prof. Desmet and Prof. Broeckhoven. The main focus of my thesis was the optimization of separation performance at 1200 bar, by using coupled core-shell particulate columns for the separation of small molecules (waste water pollutants) and biomolecules (peptides).
For my dissertation I will be focusing on the optimization of the detection limit and separation performance of multidimensional separations. Sample enrichment parameters (enrichment column size, mobile phase temperature, etc.) and design of enrichment device (Figure 1) will be investigated. One of the applications where sample enrichment is of big importance is for impurity profiling of drugs. Another application where, due to dilution effects, enrichment of analytes is very useful is for therapeutic protein profiling with comprehensive online 2D-LC.
Figure: Enrichment of analyte peak inside a switching valve (A) with a micromachined preconcentration design (B) and the simulated effect of sample enrichment (C)
Bachelor of Science in Chemistry (Ghent University): bachelor thesis on quantitative GC-MS analysis of essential oils.
Master of Science in Analytical Chemistry (Ghent University, Vrije Universiteit Brussel): master thesis on optimization of separation performance using coupled core-shell columns at 1200 bar.
- De Vos, J., Stassen, C., Vaast, A., Desmet, G., Eeltink, S., High-resolution separations of tryptic digest mixtures using core–shell particulate columns operated at 1200 bar, J. Chromatogr. A, 1264 (2012) 57 – 62.
- Vaast, A., De Vos, J., Broeckhoven, K., Verstraeten, M., Eeltink, S., Desmet, G., Maximizing the peak capacity using coupled columns packed with 2.6 um core-shell particles operated at 1200 bar, J. Chromatogr. A, 1256 (2012) 72 – 79.